Hb Avicenna	beta47(CD6)Asp->Ala

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at both alkaline and acidic pH; Hb X moves like Hb S at pH 8.5 and 6.2
CHROMATOGRAPHY		Hb X was isolated by DEAE-cellulose chromatography
STRUCTURE STUDIES		Tryptic digestion; fingerprinting; amino acid analysis; thermolytic digestion
DNA ANALYSES		Not reported; presumed mutation GAT->GCT at codon 47
FUNCTION STUDIES		Not reported
STABILITY		Normal
OCCURRENCE		Found in a young Iranian male
OTHER INFORMATION		Quantity in the heterozygote 40%

REFERENCES
1.		Rahbar, S., Nozari, G., and Ala, F.: Biochim. Biophys. Acta, 576:466, 1979.

---

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.