Hb Alesha beta67(E11)Val->Met
CONTACT Heme contact
HEMATOLOGY Inclusion body hemolytic anemia, reticulocytosis; no cyanosis; Heinz bodies; no methemoglobinemia
ELECTROPHORESIS No separation by standard procedures
CHROMATOGRAPHY Partial separation of Hb X and Hb A by cation exchange HPLC; no separation of betaX and betaA by reversed phase HPLC
STRUCTURE STUDIES Not reported; identification through DNA analysis
DNA ANALYSES A GTG->ATG mutation at codon 67
FUNCTION STUDIES Slightly increased auto-oxidation
OCCURRENCE Found in a young Russian boy but not in his parents
OTHER INFORMATION Quantity in the heterozygote 18-25
1. Molchanova, T.P., Postnikov, Yu.V., Pobedimskaya, D.D., Smetanina, N.S., Moschan, A.A., Kazanetz, E.G., Tokarev, Yu.N., and Huisman, T.H.J.: Hemoglobin, 17:217, 1993.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.