Hb Alabama beta39(C5)Gln->Lys
CONTACT alpha1beta2 contact
HEMATOLOGY Mild anemia in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH; Hb X moves to the position of Hb S
CHROMATOGRAPHY Hb X was isolated by DEAE-Sephadex chromatography; Hb X elutes between Hb A and Hb A2
STRUCTURE STUDIES Tryptic digestion; cation exchange chromatography; amino acid analysis
DNA ANALYSES Not reported; presumed mutation CAG->AAG at codon 39
STABILITY Not performed
OCCURRENCE Found in a Black family from Alabama, USA
OTHER INFORMATION Quantity in the heterozygote 38%
1. Brimhall, B., Jones, R.T., Schneider, R.G., Hosty, T.S., Tomlin, G., and Atkins, R.: Biochim. Biophys. Acta, 379:28, 1975.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.