Hb Zambia alpha60(E9)Lys->Asn
         
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Only studied by paper electrophoresis; it moves faster than Hb A at alkaline pH
CHROMATOGRAPHY Not reported
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES Not reported; presumed mutation AAG->AAC or AAT; alpha2 or alpha1
FUNCTIONAL STUDIES Not reported
STABILITY Not reported
OCCURRENCE Found in four unrelated families in Zambia
OTHER INFORMATION None
       
REFERENCES
1. Barclay, G.P.T., Charlesworth, D., and Lehmann, H.: Br. Med. J., 4:595, 1969.


This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.