Hb Suan-Dok alpha109(G16)Leu->Arg
CONTACT Internal
HEMATOLOGY Mild alpha-thal with microcytosis and hypochromia in the heterozygote
ELECTROPHORESIS Hb X moves slower than Hb F at alkaline pH and by IEF
CHROMATOGRAPHY Hb X was isolated on a DEAE-Sephadex column
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES A CTG->CGG mutation at codon 109 of the alpha2 gene (Ref. 2)
OCCURRENCE Found in a Thai female
OTHER INFORMATION Quantity in the heterozygote 8.8%; found in combination with alpha-thal-1 to give Hb H disease
1. Sanguansermsri, T., Matragoon, S., Changloah, L., and Flatz, G.: Hemoglobin, 2:161, 1979.
2. Hundrieser, J., Sanguansermsri, T., Laig, M., Pape, M., Kuhnau, W., and Flatz, G.: Hemoglobin, 14:69, 1990.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.