Hb Spanish Town | alpha27(B8)Glu->Val |
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CONTACT | External; surface crevice | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves between Hb S and Hb F at alkaline pH; like Hb A at acidic pH | ||
CHROMATOGRAPHY | The variant was isolated by anion exchange HPLC | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by cation exchange chromatography; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation GAG->GTG; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Normal to mildly unstable | ||
OCCURRENCE | Found in a Black Jamaican family | ||
OTHER INFORMATION | Quantity in heterozygotes 11-12% |
REFERENCES | |||
1. | Ahern, E., Ahern, V., Holder, W., Palomino, E., Serjeant, G.R., Serjeant, B.E., Forbes, M., Brimhall, B., and Jones, R.T.: Biochim. Biophys. Acta, 427:530, 1976. |