Hb Shuangfeng	alpha27(B8)Glu->Lys

CONTACT		External; surface crevice
HEMATOLOGY		Hemolytic anemia in the heterozygote
ELECTROPHORESIS		Hb X moves between Hb S and Hb C on cellulose acetate (pH 8.6); moves with Hb A on citrate agar (pH 6.0)
CHROMATOGRAPHY		Hb X was isolated by DE-52 cellulose chromatography
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation GAG->AAG; alpha2 or alpha1
FUNCTIONAL STUDIES		Not reported
STABILITY		Unstable
OCCURRENCE		Found in six members of a Chinese family
OTHER INFORMATION		Quantity in heterozygotes about 13%

REFERENCES
1.		Liang, C., Tao, H., Lo, H., Huang, S., Li, R., and Wang, B.: Hemoglobin, 5:691, 1981.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.