Hb Reims	alpha23(B4)Glu->Gly

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves slower than Hb A at alkaline pH; good separation by IEF
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting on an HPLC column; amino acid analysis; sequencing of the alphaT-4 peptide
DNA ANALYSES		Not reported; presumed mutation GAG->GGG; alpha2 or alpha1
FUNCTIONAL STUDIES		Normal
STABILITY		Slightly unstable
OCCURRENCE		Found in a 60-year-old French woman
OTHER INFORMATION		Quantity in the heterozygote ~31%

REFERENCES
1.		Bardakdjian-Michau, J., Rosa, J., Galactéros, F., Lancelot, M., and Marquart, F.X.: Hemoglobin, 13:733, 1989.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.