Hb Ottawa | alpha15(A13)Gly->Arg |
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ALSO KNOWN AS | Siam | ||
CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves close to Hb S on paper (pH 8.9) and with Hb A on citrate agar (pH 6.1); it is slower than Hb F on starch gel (pH 8.6) | ||
CHROMATOGRAPHY | Hb X can be isolated from Hb A by cation and anion exchange chromatography | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; carboxypeptidase B digestion | ||
DNA ANALYSES | Not reported; presumed mutation GGT->CGT; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Normal | ||
OCCURRENCE | Found in a Polish-Canadian family and in a Chinese male from Thailand | ||
OTHER INFORMATION | Quantity in heterozygotes 15-25% |
REFERENCES | |||
1. | Vella, F., Casey, R., Lehmann, H., Labossierre, A., and Jones, T.G.: Biochim. Biophys. Acta, 336:25, 1974. | ||
2. | Pootrakul, S., Srichiyanont, S., Wasi, P., and Suanpan, S.: Humangenetik, 23:199, 1974. |