Hb Jackson | alpha127(H10)Lys->Asn |
---|
CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves to the position of Hb J-Baltimore at alkaline pH | ||
CHROMATOGRAPHY | Hb X was isolated by DEAE-Sephadex or DEAE-cellulose chromatography | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting or cation exchange chromatography; chymotrypsin; amino acid analysis; sequen-cing; carboxypeptidase C; aminopeptidase M; chymotryptic digestion of the oxidized core | ||
DNA ANALYSES | Not reported; presumed mutation AAG->AAT or AAC; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Normal | ||
OCCURRENCE | Found in a few Black families from the Southeastern USA | ||
OTHER INFORMATION | Quantity in the heterozygote 20-25% |
REFERENCES | |||
1. | Moo-Penn, W.F., Bechtel, K.C., Johnson, M.H., Jue, D.L., Holland, S., Huff, C., and Schmidt, R.M.: Am. J. Clin. Pathol., 66:453, 1976. | ||
2. | Lam, H., Webber, B.B., Wilson, J.B., and Huisman, T.H.J.: J. Chromatogr., 269: 119, 1983. |