Hb J-Wenchang-Wuming alpha11(A9)Lys->Gln
         
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves faster than Hb A at alkaline pH (8.6)
CHROMATOGRAPHY Not reported
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; HPLC; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation AAG->CAG; alpha2 or alpha1
FUNCTIONAL STUDIES Not reported
STABILITY Normal
OCCURRENCE Found in five persons in a Chinese family
OTHER INFORMATION Quantity in heterozygotes 20%
       
REFERENCES
1. Chen, S-S., Liang, L-L., Jia, P-C., Yang, K-G., Chen, L-C., and Chen, L-F.: Zhongguo Kexue (series B), 26(3):243, 1983.
2. Zeng, Y-T., Huang, S-Z., Liang, X., Long, G-F., Lam, H., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 5:679, 1981.


This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.