Hb J-Meerut	alpha120(H3)Ala->Glu

ALSO KNOWN AS		J-Birmingham
CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves to the position of Hb J at alkaline pH; excellent separation by IEF
CHROMATOGRAPHY		Hb X and Hb A separate in cation and anion exchange chromatography
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES		A GCG->GAG mutation has been found in codon 120 of both the alpha2 and alpha1 genes (Ref. 5)
FUNCTIONAL STUDIES		Not reported
STABILITY		Stable
OCCURRENCE		Found in an Indian family and in families from Japan and Turkey
OTHER INFORMATION		Quantity for alpha2 heterozygotes was 23%, and 19.7% for an alpha1 heterozygote (Ref. 5)

REFERENCES
1.		Blackwell, R.Q., Wong, H.B., Wang, C-L., Weng, M-I., and Liu, C-S.: Biochim. Biophys. Acta, 351:7, 1974.
2.		Kamuzora, H., Lehmann, H., Griffiths, K.D., Mann, J.R., and Raine, D.N.: Ann. Clin. Biochem., 11:53, 1974.
3.		Harano, T., Harano, K., Imai, K., Yunoki, H., Yagi, H., Nagashima, K., and Kuroume, T.: Hemoglobin, 13:169, 1989.
4.		Yalçin, A., Avcu, F., Beyan, C., Gürgey, A., and Ural, A.U.: Hemoglobin, 18:433, 1994.
5.		Molchanova, T.P., Pobedimskaya, D.D., and Huisman, T.H.J.: Br. J. Haematol., 88:300, 1994.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.