Hb Iwata | alpha87(F8)His->Arg |
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CONTACT | Heme contact; proximal histidine | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves slower than Hb A on starch gel and cellulose acetate at alkaline pH | ||
CHROMATOGRAPHY | Hb X was isolated on a DE-52 cellulose column | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation CAC->CGC; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Mildly unstable | ||
OCCURRENCE | Found in Japanese and Chinese families | ||
OTHER INFORMATION | Quantity in heterozygotes 5-10%; abnormal spectrum of oxy-Hb; spectrum of cyan-ferriHb is normal; variant carries two heme groups/tetramer |
REFERENCES | |||
1. | Ohba, Y., Miyaji, T., Hattori, Y., Fuyuno, K., and Matsuoka, M.: Hemoglobin, 4: 307, 1980. | ||
2. | Liu, G-Y., Zhang, G-X., Nie, S-Y., Luo, H-Y., Teng, Y-Q., Liu, S-P., Song, M., Son, L., Chen, S-S., Jia, P-C., and Liang, C-C.: Hemoglobin, 7:279, 1983. |