Hb Harbin	alpha16(A14)Lys->Met

CONTACT		External
HEMATOLOGY		Proband was anemic
ELECTROPHORESIS		Hb X was identified as a fast-moving band with a mobility like Hb J; the variant moves ahead of Hb A at alkaline pH
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis of a few tryptic peptides
DNA ANALYSES		Not reported; presumed mutation AAG->ATG; alpha2 or alpha1
FUNCTIONAL STUDIES		Slightly increased oxygen affinity
STABILITY		Slightly unstable
OCCURRENCE		Found in a 30-year-old Chinese woman
OTHER INFORMATION		Quantity in the heterozygote 18%

REFERENCES
1.		Zeng, Y-T., Huang, S-Z., Qiu, X-K., Cheng, G-C., Ren, Z-R., Jin, Q-C., Chen, C-Y., Jiao, C-T., Tang, Z-G., Liu, R-H., Bao, X-H., Zeng, L-Z., Duan, Y-Q., and Zhang, G-Y.: Hemoglobin, 8:569, 1984.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.