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ALSO KNOWN AS | |
Munakata | |
CONTACT | |
External | |
HEMATOLOGY | |
Normal in the heterozygote | |
ELECTROPHORESIS | |
Hb X moves ahead of Hb A on starch gel at alkaline pH; moves anodally to Hb A on IEF | |
CHROMATOGRAPHY | |
Hb X was isolated on a DEAE-cellulose column | |
STRUCTURE STUDIES | |
Tryptic digestion; separation of peptides by fingerprinting or reversed phase HPLC; amino acid analysis | |
DNA ANALYSES | |
Not reported; presumed mutation AAG->ATG; alpha2 or alpha1 | |
FUNCTIONAL STUDIES | |
Normal oxygen affinity, Bohr effect, and cooperativity | |
STABILITY | |
Normal | |
OCCURRENCE | |
Found in Japanese families | |
OTHER INFORMATION | |
Quantity in the heterozygote 17-19% | |
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REFERENCES |
1. | |
Harano, T., Harano, K., Shibata, S., Ueda, S., Imai, K., and Seki, M.: Hemoglobin, 6:379, 1982. | |
2. | |
Sugihara, J., Imamura, T., Kagimoto, M., Matsuo, T., Yamada, H., Imoto, T., and Yanase, T.: Biochim. Biophys. Acta, 744:119, 1983. | |
3. | |
Hidaka, K., Iuchi, I., Shimasaki, S., Mizuta, W., Takatsuka, M., Mori, T., Tohdoh, A., and Matsuo, M.: Hemoglobin, 10:65, 1986. | |