Hb Chiapas alpha114(GH2)Pro->Arg
CONTACT alpha1beta1 contact
HEMATOLOGY Not reported
ELECTROPHORESIS Hb X is slightly faster than Hb S at alkaline pH
CHROMATOGRAPHY Hb X was isolated on an Amberlite IRC-50 column
STRUCTURE STUDIES Tryptic digestion; separation of peptides by cation exchange chromatography; amino acid analysis
DNA ANALYSES Not reported; presumed mutation CCC->CGC; alpha2 or alpha1
STABILITY Not reported
OCCURRENCE Found in a Mexican family
OTHER INFORMATION Quantity in the heterozygote ~25%
1. Jones, R.T., Brimhall, B., and Lisker, R.: Biochim. Biophys. Acta, 154:488, 1968.
2. Ibarra, B., Franco-Gamboa, E., Ramirez, M.L., Cantu, J.M., Wilson, J.B., Lam, H., and Huisman, T.H.J.: Hemoglobin, 5:605, 1981.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.