Hb Bourmedès	alpha37(C2)Pro->Arg

CONTACT		Internal
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X separates from Hb A at alkaline pH; its mobility is between Hb S and Hb A2; excellent separation by IEF
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting or reversed phase HPLC; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation CCC->CGC; alpha2 or alpha1
FUNCTIONAL STUDIES		Not studied
STABILITY		Not studied
OCCURRENCE		Found in an Algerian family; the proband was also homozygous for Hb S
OTHER INFORMATION		Quantity in the heterozygote 16-20%

REFERENCES
1.		Dahmane-Arbane, M., Blouquit, Y., Arous, N., Bardakdjian, J., Benamani, M., Riou, J., Benabadji, M., Rosa, J., and Galacteros, F.: Nouv. Rev. Fr. d'Hematol., 29:317, 1987.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.