Hb Aztec | alpha76(EF5)Met->Thr |
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CONTACT | Internal | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | No separation observed at alkaline and acidic pH | ||
CHROMATOGRAPHY | Hb X and Hb A apparently do not separate by cation or anion exchange HPLC; the variant was detected as an abnormal alpha chain by reversed phase HPLC | ||
STRUCTURE STUDIES | Tryptic peptides were separated by reversed phase HPLC; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation ATG->ACG; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Normal | ||
STABILITY | Not reported | ||
OCCURRENCE | Found in a newborn and her mother of native Mexican and Spanish descent | ||
OTHER INFORMATION | None |
REFERENCES | |||
1. | Shelton, J.B., Shelton, J.R., Schroeder, W.A., and Powars, D.R: Hemoglobin, 9:325, 1985. |