Hb Aichi alpha50(CE8)His->Arg
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A can best be separated by IEF; Hb X moves slower than Hb A
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES Not reported; presumed mutation CAC->CGC; alpha2 or alpha1
FUNCTIONAL STUDIES Normal oxygen affinity
STABILITY Slightly unstable
OCCURRENCE Found in a Japanese family
OTHER INFORMATION Quantity in heterozygotes 21-22%
1. Harano, T., Harano, K., Shibata, S., Ueda, S., Mori, H., and Seki, M.: FEBS Lett., 169:297, 1984.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.