Hb F-Xin-Su Agamma73(E17)Asp->His
ELECTROPHORESIS Hb FX moves between Hb A and Hb S at alkaline pH
IEF Not reported
CHROMATOGRAPHY Hb FX can readily be isolated by DEAE-cellulose chromatography
CHAIN SEPARATION AgammaX = 12.7%; AgammaT = 14.9%; Ggamma = 72.4%
STRUCTURE STUDIES Tryptic digestion of gammaX chain; separation of peptides by fingerprinting or reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation GAT->CAT at codon 73
NOTES Found in a Chinese baby of the Han nationality; the baby was also heterozygous for the AgammaT chain
1. Ma, M., Hu, H., Kutlar, F., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 11:473, 1987.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.