Hb F-Texas-I	Agamma5(A2)Glu->Lys

ELECTROPHORESIS		Hb FX moves slower than Hb C at alkaline pH
IEF		About the same
CHROMATOGRAPHY		Hb FX can be isolated by cation and anion exchange HPLC
CHAIN SEPARATION		No data reported
STRUCTURE STUDIES		Tryptic digestion of Hb FX; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation GAG->AAG at codon 5
NOTES		Found in several Black babies; quantity in heterozygotes ~12%; the gamma-Texas-I chain is considerably acetylated (three time more than the normal gamma chain)

REFERENCES
1.		Jenkins, G.C., Beale, D., Black, A.J., Huntsman, G.R., and Lehmann, H.: Br. J. Haematol., 13:252, 1967.
2.		Ahern, E.J., Wiltshire, B.G., and Lehmann, H.; Biochim. Biophys. Acta, 271:61, 1972.
3.		Keitt, A.S. and Jones, R.T.: Am. J. Hematol., 28:47, 1988.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.