Hb F-Pordenone | Agamma6(A3)Glu->Gln |
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ELECTROPHORESIS | Hb FX moves slightly slower than Hb S at alkaline pH | ||
IEF | Not reported | ||
CHROMATOGRAPHY | Hb FX elutes between Hb A2 and Hb A on a DEAE-cellulose column | ||
CHAIN SEPARATION | Not reported | ||
STRUCTURE STUDIES | Tryptic digestion of gammaX chain; separation of peptides by reversed phase HPLC; amino acid analysis; sequencing | ||
DNA ANALYSES | Not reported; presumed mutation GAG->CAG at codon 6 | ||
NOTES | Found in an Italian newborn; Hb FX 5.7 of total Hb and 8.6% of total Hb F |
REFERENCES | |||
1. | Nakatsuji, T., Webber, B., Lam, H., Wilson, J.B., Huisman, T.H.J., Sciarratta, G.V., Sansone, G., and Molaro, G.L.: Hemoglobin, 6:397, 1982. |