Hb F-Pordenone	Agamma6(A3)Glu->Gln

ELECTROPHORESIS		Hb FX moves slightly slower than Hb S at alkaline pH
IEF		Not reported
CHROMATOGRAPHY		Hb FX elutes between Hb A2 and Hb A on a DEAE-cellulose column
CHAIN SEPARATION		Not reported
STRUCTURE STUDIES		Tryptic digestion of gammaX chain; separation of peptides by reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation GAG->CAG at codon 6
NOTES		Found in an Italian newborn; Hb FX 5.7 of total Hb and 8.6% of total Hb F

REFERENCES
1.		Nakatsuji, T., Webber, B., Lam, H., Wilson, J.B., Huisman, T.H.J., Sciarratta, G.V., Sansone, G., and Molaro, G.L.: Hemoglobin, 6:397, 1982.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.