Hb F-Macedonia-I | Agamma2(NA2)His->Gln |
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ELECTROPHORESIS | Hb FX was detected by PAGE | ||
IEF | Not reported | ||
CHROMATOGRAPHY | Not reported | ||
CHAIN SEPARATION | AgammaX = 15%; Ggamma = 70.8%; Agamma = 14.2% | ||
STRUCTURE STUDIES | Tryptic digestion of gammaX chain; separation of peptides by reversed phase HPLC; amino acid analysis identified a His-> Glu or Gln change | ||
DNA ANALYSES | A CAT->CAG (His->Gln) mutation at codon 2 | ||
NOTES | Found in a healthy Macedonian baby; Hb FX 15% of total Hb F |
REFERENCES | |||
1. | Plaseska, D., Cepreganova-Krstik, B., Momirovska, A., and Efremov, G.D.: Hemoglobin, 18:241, 1994. |