Hb F-Jamaica Agamma61(E5)Lys->Glu
ELECTROPHORESIS Hb FX moves much faster than Hb A at alkaline pH; slightly slower than Hb Bart's (or gamma4)
IEF Not reported
CHROMATOGRAPHY Hb FX was isolated by DEAE-Sephadex and Bio-Rex 70 chromatography
STRUCTURE STUDIES Tryptic digestion of AE-gammaX chain; separation of peptides by cation exchange chromatography; amino acid analysis; se-quencing
DNA ANALYSES Not reported; presumed mutation AAG->GAG at codon 61
NOTES Found in a Jamaican newborn of mixed ethnic origin; Hb FX 11-15% of total Hb F
1. Ahern, E.J., Jones, R.T., Brimhall, B., and Gray, R.H.: Br. J. Haematol., 18:369, 1970.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.