Hb F-Cobb Agamma37(C3)Trp->Gly
ELECTROPHORESIS Hb FX moves slower than Hb F at alkaline pH
IEF Not reported
CHROMATOGRAPHY Hb FX can be separated from Hb A and Hb F by DEAE-cellulose chromatography
STRUCTURE STUDIES Tryptic digestion of gammaX chain; separation of peptides by reversed phase HPLC amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation TGG->GGG at codon 37
NOTES Found in a Caucasian baby; no quantitative data at birth
1. Chen, S.S., Webber, B.B., Kutlar, A., Wilson, J.B., and Huisman, T.H.J.: 9:617, 1985.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.