Hb Mosella alpha111(G18)Ala->Thr
         
CONTACT alpha1beta1 contact
HEMATOLOGY Normal in heterozygotes
ELECTROPHORESIS Hb X focuses between Hb A and Hb A1c on IEF
CHROMATOGRAPHY Not reported
STRUCTURE STUDIES Tryptic digestion of alphaX+alphaA chains; separation of pep-tides by reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation GCC->ACC; alpha2 or alpha1
FUNCTION STUDIES Not reported
STABILITY Normal
OCCURRENCE Observed in a 35-year-old female from Luxembourg and in one of her daughters
OTHER INFORMATION Quantity of Hb X ~20%
       
REFERENCES
1. Wajcman, H., Blouquit, Y., Lahary, A., Soummer, A.M., Groff, P., Bardakdjian, J., Préhu, C., Riou, J., Godard, C., and Galactèros, F.: Hemoglobin, 19:281, 1995.


This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.