Hb Debrousse beta96(FG3)Leu->Pro
CONTACT Heme contact
HEMATOLOGY Chronic hemolytic anemia; hemoglobinuria; reticulocytosis
ELECTROPHORESIS Not easily observed by cellulose acetate electrophoresis and IEF
CHROMATOGRAPHY The betaX chain separates from betaA and alpha by reversed phase HPLC
STRUCTURE STUDIES Tryptic digestion of AE-betaX chain; separation of peptides by reversed phase HPLC; amino acid analysis
DNA ANALYSES A CTG->CCG mutation at codon 96
FUNCTION STUDIES Increased oxygen affinity; normal Bohr effect
STABILITY Decreased stability
OCCURRENCE Found in a 6-year-old of Italian/French descent; parents are normal
OTHER INFORMATION betaX = 35% of betaA+betaX
1. Lacan, P., Kister, J., Francina, A., Souillet, G., Galactéros, F., Delaunay, J., and Wajcman, H.: Am. J. Hematol., 51:276, 1996.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.