Table XIII

TABLE XIII.

Beta-Thalassemia in the Chinese (number of chromosomes) (references in parentheses)

Allele South & SW PRC
(1,2) Taiwan
(3,4) Hong Kong
(5) Macau
(6) Malaysia
(7) Total

-29, A->G 8 4 1 2 1 16

-28, A->G 12 36 8 7 7 5 8 83

+1, A->C 1 1

Codon 17, A->T 35 36 8 5 9 2 95

Codon 19, A->G 3 3

Codons 27/28, +C 2 2 4

IVS-I-1, G->T 8 2 1 11

IVS-I-5, G->C 1 1

IVS-I-128, T->G 1 12 13

Codons 41/42, -TTCT 53 83 21 28 45 14 38 282

Codon 43, G->T 3 3

Codons 71/72, +A 7 4 1 2 14

IVS-II-5, G->C 1 1

IVS-II-654, C->T 10 12 34 40 20 14 14 144

Hb Lepore 1 1

Unknown; others 1 1 0 0 0 0 0 2

TOTAL 126 188 74 86 93 35 72 674

Allele	South & SW PRC (1,2)	Taiwan (3,4)	Hong Kong (5)	Macau (6)	Malaysia (7)	Total
-29, A->G	8	4	1			2	1	16
-28, A->G	12	36	8	7	7	5	8	83
+1, A->C							1	1
Codon 17, A->T	35	36	8	5	9		2	95
Codon 19, A->G							3	3
Codons 27/28, +C			2	2				4
IVS-I-1, G->T		8		2			1	11
IVS-I-5, G->C							1	1
IVS-I-128, T->G				1	12			13
Codons 41/42, -TTCT	53	83	21	28	45	14	38	282
Codon 43, G->T		3						3
Codons 71/72, +A	7	4		1			2	14
IVS-II-5, G->C		1						1
IVS-II-654, C->T	10	12	34	40	20	14	14	144
Hb Lepore							1	1
Unknown; others	1	1	0	0	0	0	0	2
TOTAL	126	188	74	86	93	35	72	674

1. Liu, J.Z., Gao, Q.S., Jiang, Z., Liang, C.C., Yang, K.G., Wu, G.Y., Long, G.F., Li, Q., Zhang, J., Deng, B., and Wang, R.X.: Hemoglobin, 13:585, 1989.

2. Liang, R., Liang, S., Jiang, N.H., Wen, X-J., Zhao, J-B., Nechtman, J.F., Stoming, T.A., and Huisman, T.H.J.: Br. J. Haematol., 86:351, 1994.

3. Lin, L-I., Lin, K-S., Lin, K-H., and Chang, H-C.: Am. J. Hum. Genet., 48:809, 1991.

4. Chiou, S-S., Liu, T-C., Chang, T-T., Tseng, W-P., Sy, W-D., and Chang, J-G.: Personal communication, 1993.

5. Chan, V., Chan, T.K., Chehab, F.F., and Todd, D.: Am. J. Hum. Genet., 41:678, 1987.

6. Ribeiro, M.L. and Tamagnini, G.P.: Hemoglobin, 21:271, 1997.

7. George, E., Li, H-J., Fei, Y-J., Reese, A.L., Baysal, E., Cepreganova, B., Wilson, J.B., Gu, L-H., Nechtman, J.F., Stoming, T.A., Liu, J-C., Codrington, J.F., and Huisman, T.H.J.: Hemoglobin, 16: 51, 1992.

This material is from the book A Syllabus of Thalassemia Mutations (1997) by Titus H.J. Huisman, Marianne F.H. Carver, and Erol Baysal, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1997 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without permission in writing from the Author.

1.	Liu, J.Z., Gao, Q.S., Jiang, Z., Liang, C.C., Yang, K.G., Wu, G.Y., Long, G.F., Li, Q., Zhang, J., Deng, B., and Wang, R.X.: Hemoglobin, 13:585, 1989.
2.	Liang, R., Liang, S., Jiang, N.H., Wen, X-J., Zhao, J-B., Nechtman, J.F., Stoming, T.A., and Huisman, T.H.J.: Br. J. Haematol., 86:351, 1994.
3.	Lin, L-I., Lin, K-S., Lin, K-H., and Chang, H-C.: Am. J. Hum. Genet., 48:809, 1991.
4.	Chiou, S-S., Liu, T-C., Chang, T-T., Tseng, W-P., Sy, W-D., and Chang, J-G.: Personal communication, 1993.
5.	Chan, V., Chan, T.K., Chehab, F.F., and Todd, D.: Am. J. Hum. Genet., 41:678, 1987.
6.	Ribeiro, M.L. and Tamagnini, G.P.: Hemoglobin, 21:271, 1997.
7.	George, E., Li, H-J., Fei, Y-J., Reese, A.L., Baysal, E., Cepreganova, B., Wilson, J.B., Gu, L-H., Nechtman, J.F., Stoming, T.A., Liu, J-C., Codrington, J.F., and Huisman, T.H.J.: Hemoglobin, 16: 51, 1992.