Table IX

TABLE IX.

Beta-Thalassemia Alleles in Several Middle Eastern Populations (number of chromosomes) (references in parentheses)

Jordan Syria Saudi Arabia Yemen United Arab Emirates Kuwait Iran S.W. Iran

Allele (1,2) (3) (1) (1) (1) UAE Others[1]
(4,5) Kuwait
(5) Others[2]
(6) (7) (8)

-101, C->T 1 1

-88, C->A 1 1

-87, C->G 2

+1, A->C 1 3

Initiation codon, ATG->ATT 1

Codon 5, -CT 3 11 6

Codon 6, -A 1 4

Codon 8, -AA 10 16 7 4

Codons 8/9, +G 3 1 15 27 3 5

Codon 15, TGG->TAG 2 10

Codon 16, -C 9

Codon 19, A->G[3] 1

Codons 22/23/24, -AAGTTGG 2

Codon 27, G->T[4] 3 2

Codon 29, C->T

Codon 30, AGG->ACG[5] 6 4

Codon 30, AGG->AAG 2

Codon 30, AGG->AGC[6] 1

IVS-I-1, G->A 2 6 6 6 7 4

IVS-I-1, G->T 7

IVS-I-5, G->C 5 12 138 150 18 8

IVS-I-6, T->C 2 6 8 1 7 5 3

IVS-I-110, G->A 15 20 16 25 6 5 2 8 7 2

IVS-I-130, G->A 1

Codons 36/37, -T 1 11 1 2

Codon 37, TGG->TGA 8 1

Codon 39, C->T 2 4 12 10 10 7 12 6 1

Codons 41/42, -TTCT 5

Codon 44, -C 4 6 1 3

Codons 47/48, +ATCT 1

Codons 57/58, +C 1

Codons 82/83, -G 3

IVS-II-1, G->A 3 18 1 12 4 9 19 28 3 15 6

IVS-II-1, G->C 2

IVS-II-654, C->T 1

IVS-II-745, C->G 2 11 6 2 9 2

IVS-II-848, C->A 2 1

Codon 110, T->C 2

Poly A, AATAAA->AATAAG 2

Poly A, AATAAA->A- - - - - 2

Unknown; others 12 4 3 14 5 0 0 0 0 40 2

TOTAL 39 91 36 81 15 229 296 89 24 114 18

[1]   Hb Malay [beta19(B1)Asn->Ser].
[2]   Hb Knossos [beta27(B9)Ala->Ser].
[3]   Hb Monroe [beta30(B12)Arg->Thr].
[4]   Hb Tacoma [beta30(B12) Arg->Ser].
[5]   Pakistani; Indian; Bangladeshi; Iranian; Omani; etc.
[6]   Bedouin; Egyptian; Palestinian; Indian; Lebanese.

1. El-Hazmi, M.A.F., Warsy, A.S., and Al-Swailem, A.R.: Hemoglobin, 19:353, 1995.

2. El-Hazmi, M.A.F. and Al-Swailem, A.R.: Hum. Hered., 37:211, 1987.

3. Sadiq, M.F.G. and Huisman, T.H.J.: Hemoglobin, 18:325, 1994.

4. El-Kalla, S. and Mathews, A.R.: Hemoglobin, 17:355, 1993.

5. El-Kalla, S. and Mathews, A.R.: Hemoglobin, 21:237, 1997.

6. Adekile, A.D., Gu, L-H., Baysal, E., Haider, M.Z., Al-Fuzae, L., Aboobacker, K.C., Al-Rashied, A., and Huisman, T.H.J.: Acta Haematol., 92:176, 1994.

7. Nozari, G., Rahbar, S., Golshaiyzan, A., and Rahmandzadeh, S.: Hemoglobin, 19:425, 1995.

8. Merat, A., Haghshenas, M., Mostafavi Pour, Z., Plonczynski, M.W., Harrell, A.N., Coleman, M.B., and Steinberg, M.H.: Hemoglobin, 17:427, 1993.

This material is from the book A Syllabus of Thalassemia Mutations (1997) by Titus H.J. Huisman, Marianne F.H. Carver, and Erol Baysal, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1997 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without permission in writing from the Author.

	Jordan		Syria	Saudi Arabia	Yemen	United Arab Emirates		Kuwait		Iran	S.W. Iran
Allele	(1,2)	(3)	(1)	(1)	(1)	UAE	Others[1] (4,5)	Kuwait (5)	Others[2] (6)	(7)	(8)
-101, C->T						1					1
-88, C->A										1	1
-87, C->G		2
+1, A->C				1			3
Initiation codon, ATG->ATT										1
Codon 5, -CT		3				11	6
Codon 6, -A		1		4
Codon 8, -AA						10	16	7		4
Codons 8/9, +G	3			1		15	27	3		5
Codon 15, TGG->TAG						2	10
Codon 16, -C							9
Codon 19, A->G[3]										1
Codons 22/23/24, -AAGTTGG							2
Codon 27, G->T[4]		3					2
Codon 29, C->T
Codon 30, AGG->ACG[5]						6	4
Codon 30, AGG->AAG							2
Codon 30, AGG->AGC[6]						1
IVS-I-1, G->A	2	6	6				6	7		4
IVS-I-1, G->T							7
IVS-I-5, G->C		5		12		138	150	18		8
IVS-I-6, T->C	2	6				8	1	7		5	3
IVS-I-110, G->A	15	20	16	25	6	5	2		8	7	2
IVS-I-130, G->A							1
Codons 36/37, -T						1		11	1	2
Codon 37, TGG->TGA		8					1
Codon 39, C->T		2	4	12		10	10	7	12	6	1
Codons 41/42, -TTCT							5
Codon 44, -C						4	6	1		3
Codons 47/48, +ATCT							1
Codons 57/58, +C							1
Codons 82/83, -G						3
IVS-II-1, G->A	3	18	1	12	4	9	19	28	3	15	6
IVS-II-1, G->C										2
IVS-II-654, C->T										1
IVS-II-745, C->G	2	11	6				2			9	2
IVS-II-848, C->A		2				1
Codon 110, T->C						2
Poly A, AATAAA->AATAAG						2
Poly A, AATAAA->A- - - - -							2
Unknown; others	12	4	3	14	5	0	0	0	0	40	2
TOTAL	39	91	36	81	15	229	296	89	24	114	18

1.	El-Hazmi, M.A.F., Warsy, A.S., and Al-Swailem, A.R.: Hemoglobin, 19:353, 1995.
2.	El-Hazmi, M.A.F. and Al-Swailem, A.R.: Hum. Hered., 37:211, 1987.
3.	Sadiq, M.F.G. and Huisman, T.H.J.: Hemoglobin, 18:325, 1994.
4.	El-Kalla, S. and Mathews, A.R.: Hemoglobin, 17:355, 1993.
5.	El-Kalla, S. and Mathews, A.R.: Hemoglobin, 21:237, 1997.
6.	Adekile, A.D., Gu, L-H., Baysal, E., Haider, M.Z., Al-Fuzae, L., Aboobacker, K.C., Al-Rashied, A., and Huisman, T.H.J.: Acta Haematol., 92:176, 1994.
7.	Nozari, G., Rahbar, S., Golshaiyzan, A., and Rahmandzadeh, S.: Hemoglobin, 19:425, 1995.
8.	Merat, A., Haghshenas, M., Mostafavi Pour, Z., Plonczynski, M.W., Harrell, A.N., Coleman, M.B., and Steinberg, M.H.: Hemoglobin, 17:427, 1993.