TABLE VIII.   Beta-Thalassemia Alleles in Some North African Populations (number of chromosomes) (references in parentheses)

Alleles Algeria Tunisia Egypt
  (1) (2) (3) (4) (5) (6,7)
-30, T->A     3      
Codon 5, -CT     2     2
Codon 6, -A 23 11 1 2   1
Codon 8, -AA     1      
Codons 8/9, +G           1
Codon 22, A->C           15
Codons 25/26, +T     1      
Codon 28, -C           1
Codon 28/29, -G           4
Codon 30, G->C     2      
IVS-I-1, G->A 19 1   6 5 14
IVS-I-2, T->G     1      
IVS-I-5, G->A     1      
IVS-I-6, T->C 4 7   5 9 20
IVS-I-110, G->A 33 5 9 16 13 34
Codon 37, G->A         1  
Codon 39, C->T 34 13 18   1 1
Codon 44, -C     4      
IVS-II-1, G->A       3 2 3
IVS-II-745, C->G   5   1 4 8
IVS-II-848, C->A     1     4
Unknown; others 16 26 0 9 11 0
TOTAL 129 68 44 40 48 87

1. Labie, D., Bennani, C., and Beldjord, C.: Ann. N.Y. Acad. Sci., 612:43, 1990.
2. Chibani, J., Vidaud, M., Duquesnoy, P., Bergé-Lefranc, J.L., Pirastu, M., Ellouze, F., Rosa, J., and Goossens, M.: Hum. Genet., 78:190, 1988.
3. Fattoum, S., Guemira, F., Öner, C., Öner, R., Li, H-W., Kutlar, F., and Huisman, T.H.J.: Hemoglobin, 15:11, 1991.
4. El-Hazmi, M.A.F., Warsy, A.S., and Al-Swailem, A.R.: Hemoglobin, 19:353, 1995.
5. Novelletto, A., Hafez, M., Deidda, G., Di Rienzo, A., Felicetti, L., El-Tahan, H., El Morsi, Z., El-Ziny, M., Al-Tonbary, Y., Sittien, A., and Terrenato, L.: Hum. Genet., 85:272, 1990.
6. Rady, M.S., Baffico, M., Khalifa, A.S., Heshmat, N.M., El-Moselhy, S., Sciarratta, G.V., Hussein, I.R., Temtamy, S.A., and Romeo, G.: Hemoglobin, 21:59, 1997.
7. El-Hashemite, N., Petrou, M., Khalifa, A.S., Heshmat, N.M., Rady, M.S., and Delhanty, J.D.A.: Hum. Genet., 99:271, 1997.


This material is from the book A Syllabus of Thalassemia Mutations (1997) by Titus H.J. Huisman, Marianne F.H. Carver, and Erol Baysal, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1997 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without permission in writing from the Author.