Hb Tours | beta87(F3)Thr->0 |
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HEMATOLOGY | Mild hemolytic anemia in the heterozygote | ||
ELECTROPHORESIS | Hb X moves like Hb S at alkaline pH | ||
CHROMATOGRAPHY | Hb X was isolated on a cation exchange (Bio-Rex 70) column | ||
STRUCTURE STUDIES | Tryptic digestion of AE-betaX chain; separation of peptides by cation exchange chromatography; amino acid analysis; sequencing | ||
DNA ANALYSES | Not reported | ||
FUNCTION STUDIES | Increased oxygen affinity; the unstable Hb readily loses heme | ||
STABILITY | Unstable | ||
OCCURRENCE | Found in a 40-year-old French male | ||
OTHER INFORMATION | Quantity in the heterozygote about 25% |
REFERENCES | |||
1. | Najman, A., Duhamel, G., Andre, R., Buc, H., Wajcman, H., Labie, D., and Schapira, G.: Nouv. Rev. Fr. d'Hematol., 13:803, 1973. | ||
2. | Wajcman, H., Labie, D., and Schapira, G.: Biochim. Biophys. Acta, 295:495, 1973. |