Hb Tochigi | beta56(D7)-beta59(E3) Gly-Asn-Pro-Lys->0 |
---|
HEMATOLOGY | Chronic hemolytic anemia | ||
ELECTROPHORESIS | Hb X moves ahead of Hb A at alkaline pH; Hb X moves faster to the anode than Hb A at acidic pH | ||
CHROMATOGRAPHY | Not reported | ||
STRUCTURE STUDIES | pCMB; tryptic digestion; separation of peptides by fingerprinting; amino acid analysis | ||
DNA ANALYSES | Not done | ||
FUNCTION STUDIES | Not reported; metHb | ||
STABILITY | Unstable | ||
OCCURRENCE | Found in three members of a Japanese family | ||
OTHER INFORMATION | Quantity in the heterozygote 20-25% |
REFERENCES | |||
1. | Shibata, S., Miyaji, T., Ueda, S., Matsuoka, M., Iuchi, I., Yamada, K., and Shinkai, N.: Proc. Jpn. Acad., 46:440, 1970. | ||
2. | Yamada, K., Shinkai, N., Nakazawa, S., Yamada, Z., Saito, K., Miwa, S., Miyaji, T., and Shibata, S.: Acta Haematol. Jap., 34:484, 1971. |