Hb Tochigi beta56(D7)-beta59(E3) Gly-Asn-Pro-Lys->0
         
HEMATOLOGY Chronic hemolytic anemia
ELECTROPHORESIS Hb X moves ahead of Hb A at alkaline pH; Hb X moves faster to the anode than Hb A at acidic pH
CHROMATOGRAPHY Not reported
STRUCTURE STUDIES pCMB; tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES Not done
FUNCTION STUDIES Not reported; metHb
STABILITY Unstable
OCCURRENCE Found in three members of a Japanese family
OTHER INFORMATION Quantity in the heterozygote 20-25%
       
REFERENCES
1. Shibata, S., Miyaji, T., Ueda, S., Matsuoka, M., Iuchi, I., Yamada, K., and Shinkai, N.: Proc. Jpn. Acad., 46:440, 1970.
2. Yamada, K., Shinkai, N., Nakazawa, S., Yamada, Z., Saito, K., Miwa, S., Miyaji, T., and Shibata, S.: Acta Haematol. Jap., 34:484, 1971.


This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.