Hb Lyon | beta17(A14)-beta18(A15) Lys-Val->0 |
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HEMATOLOGY | Slight anemia in the heterozygote; Heinz bodies present after treatment with acetylphenylhydrazine | ||
ELECTROPHORESIS | Hb X moves faster than Hb A in cellulose acetate electrophoresis at alkaline pH | ||
CHROMATOGRAPHY | Not reported | ||
STRUCTURE STUDIES | Tryptic digestion of betaX chain; separation of peptides by fingerprinting and cation exchange chromatography; amino acid analysis; final identification made with an automatic sequenator | ||
DNA ANALYSES | Not done | ||
FUNCTION STUDIES | Increased oxygen affinity | ||
STABILITY | Slightly unstable | ||
OCCURRENCE | Found in members of a French-Spanish-North African family living in France | ||
OTHER INFORMATION | Quantity in the heterozygote 37% |
REFERENCES | |||
1. | Cohen-Solal, M., Blouquit, Y., Garel, M.C., Thillet, J., Gaillard, L., Creyssel, R., Gibaud, A., and Rosa, J.: Biochim. Biophys. Acta, 351:306, 1974. |