Hb Lyon beta17(A14)-beta18(A15) Lys-Val->0
HEMATOLOGY Slight anemia in the heterozygote; Heinz bodies present after treatment with acetylphenylhydrazine
ELECTROPHORESIS Hb X moves faster than Hb A in cellulose acetate electrophoresis at alkaline pH
STRUCTURE STUDIES Tryptic digestion of betaX chain; separation of peptides by fingerprinting and cation exchange chromatography; amino acid analysis; final identification made with an automatic sequenator
FUNCTION STUDIES Increased oxygen affinity
STABILITY Slightly unstable
OCCURRENCE Found in members of a French-Spanish-North African family living in France
OTHER INFORMATION Quantity in the heterozygote 37%
1. Cohen-Solal, M., Blouquit, Y., Garel, M.C., Thillet, J., Gaillard, L., Creyssel, R., Gibaud, A., and Rosa, J.: Biochim. Biophys. Acta, 351:306, 1974.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.