Hb F-Yamaguchi | Agamma80(EF4)Asp->Asn; 75(E19)Ile->Thr |
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ELECTROPHORESIS | Hb FX moves between Hb S and Hb C at alkaline pH | ||
IEF | About the same | ||
CHROMATOGRAPHY | Hb FX can be isolated by DEAE-cellulose chromatography | ||
CHAIN SEPARATION | Not reported | ||
STRUCTURE STUDIES | Tryptic digestion of gammaX chain; separation of peptides by fingerprinting or reversed phase HPLC; amino acid analysis; sequencing | ||
DNA ANALYSES | Not reported; presumed mutation GAT->AAT at codon 80 | ||
NOTES | Found in Japanese newborn babies; quantity in the heterozygote 30-35%; its occurrence is associated with a Ggamma-thal |
REFERENCES | |||
1. | Fuyuno, K., Torigoe, T., Ohba, Y., Matsuoka, M., and Miyaji, T.: Hemoglobin, 5:139, 1981. | ||
2. | Nakatsuji, T., Ohba, Y., and Huisman, T.H.J.: Am. J. Hematol., 16:189, 1984. | ||
3. | Wada, Y., Fujita, T., Kidoguchi, K., and Hayashi, A.: Hum. Genet., 72:196, 1986. |