Hb F-Siena Agamma121(GH4)Glu->Lys; 75(E19)Ile->Thr
ELECTROPHORESIS Hb FX moves slower than Hb A2 at alkaline pH
IEF Not reported
STRUCTURE STUDIES Tryptic digestion of gammaX chain; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES Not reported; presumed mutation GAA->AAA at codon 121
NOTES Found in an Italian baby; quantity in the heterozygote ~20% of total Hb
1. Carè, A., Marinucci, M., Massa, A., Maffi, D., Sposi, N.M., Improta, T., and Tentori, L.: Hemoglobin, 7:79, 1983.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.