Hb Parchman | Two crossovers have been described: |
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a) deltabeta hybrid (delta through 12; beta from 22); | |
b) betadelta hybrid (beta from 22 through 50; delta from 87) |
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves like Hb S at alkaline pH | ||
CHROMATOGRAPHY | Hb X was isolated on a DEAE-Sephadex column | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by cation exchange chromatography; amino acid analysis; sequencing | ||
DNA ANALYSES | Gene mapping identified a deltabetadelta gene | ||
FUNCTION STUDIES | Not reported | ||
STABILITY | Normal | ||
OCCURRENCE | Found in a Black male living in Mississippi | ||
OTHER INFORMATION | Quantity in the heterozygote 1.6%; found in a patient who was heterozygous for alpha-thal-2 |
REFERENCES | |||
1. | Adams, J.G., III, Morrison, W.T., and Steinberg, M.H.: Science, 218:291, 1982. |