Hb Miyada betadelta hybrid (beta through 12; delta from 22)
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves like Hb A2 at alkaline pH
CHROMATOGRAPHY Hb X was isolated on a DEAE-Sephadex column
STRUCTURE STUDIES Tryptic digestion; separation of peptides by cation exchange chromatography; amino acid analysis
DNA ANALYSES Gene mapping has identified this betadelta hybrid to be located between a delta and a beta gene; the hybrid gene results from a non-homologous crossover between beta and delta genes
STABILITY Not reported
OCCURRENCE Found in a Japanese family and in a 24-year-old Italian male
OTHER INFORMATION Quantity in heterozygotes 17%; found in association with beta+-thal
1. Yanase, T., Hanada, M., Seita, M., Ohya, I., Ohta, Y., Imamura, T., Fujimura, T., Kawasaki, K., and Yamaoka, K.: Jpn. J. Hum. Genet., 13:40, 1968.
2. Ohta, Y., Yamaoka, K., Sumida, I., and Yanase, T.: Nature, 234:218, 1971.
3. Roberts, A.V., Clegg, J.B., Weatherall, D.J., and Ohta, Y.: Nature, 245:23, 1973.
4. Driscoll, M.C., Baird, M., Ohta, Y., and Bank, A.: Blood, 58:53a (Suppl. 1), 1981.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.