Hb Lincoln Park betadelta hybrid (beta through 22; delta from 50)as in Hb P-Nilotic
but with the deletion of a valine residue at delta137
HEMATOLOGY Mild hemolytic anemia; reticulocytosis
ELECTROPHORESIS Hb X moves slightly faster than Hb S at alkaline pH; and by IEF
CHROMATOGRAPHY Hb X was isolated on a DEAE-Sephadex column
STRUCTURE STUDIES Tryptic digestion of AE-betadelta chain; separation of peptides by cation exchange chromatography; amino acid analysis; Edman PTH degradation
DNA ANALYSES Not reported; presumably a P-Nilotic betadelta gene with an additional deletion of a GTG triplet at codon 137
FUNCTION STUDIES Normal oxygen affinity
OCCURRENCE Found in members of a family in Southern Mexico
OTHER INFORMATION Quantity in the heterozygote 14%; decreased globin chain synthesis in reticulocytosis
1. Honig, G.R., Shamsuddin, M., Mason, R.G., and Vida, L.N.: Proc. Natl. Acad. Sci. USA, 75:1475, 1978.
2. Honig, G.R., Mason, R.G., Tremaine, L.M., and Vida, L.N.: Am. J. Hematol., 5:335, 1978.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.