Hb Lincoln Park	betadelta hybrid (beta through 22; delta from 50)as in Hb P-Nilotic
	but with the deletion of a valine residue at delta137

HEMATOLOGY		Mild hemolytic anemia; reticulocytosis
ELECTROPHORESIS		Hb X moves slightly faster than Hb S at alkaline pH; and by IEF
CHROMATOGRAPHY		Hb X was isolated on a DEAE-Sephadex column
STRUCTURE STUDIES		Tryptic digestion of AE-betadelta chain; separation of peptides by cation exchange chromatography; amino acid analysis; Edman PTH degradation
DNA ANALYSES		Not reported; presumably a P-Nilotic betadelta gene with an additional deletion of a GTG triplet at codon 137
FUNCTION STUDIES		Normal oxygen affinity
STABILITY		Normal
OCCURRENCE		Found in members of a family in Southern Mexico
OTHER INFORMATION		Quantity in the heterozygote 14%; decreased globin chain synthesis in reticulocytosis

REFERENCES
1.		Honig, G.R., Shamsuddin, M., Mason, R.G., and Vida, L.N.: Proc. Natl. Acad. Sci. USA, 75:1475, 1978.
2.		Honig, G.R., Mason, R.G., Tremaine, L.M., and Vida, L.N.: Am. J. Hematol., 5:335, 1978.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.