Hb F-Shanghai Ggamma66(E10)Lys->Arg
         
ELECTROPHORESIS No separation reported
IEF No separation reported
CHROMATOGRAPHY Not reported; no separation by DEAE-cellulose chromatography
CHAIN SEPARATION GgammaX = 35.5% of total gamma; Ggamma = 37.9%; Agamma = 26.6%
STRUCTURE STUDIES Tryptic digestion of gammaX chain; separation of peptides by reversed phase HPLC; amino acid analysis
DNA ANALYSES Not reported; presumed mutation AAG->AGG at codon 66
NOTES Found in a Chinese newborn
       
REFERENCES
1. Zeng, Y-T., Huang, S-Z., Nakatsuji, T., and Huisman, T.H.J.: Am. J. Hematol., 18: 235, 1985.


This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.