Hb F-Sacromonte Ggamma59(E3)Lys->Gln
         
ALSO KNOWN AS F-Foch
ELECTROPHORESIS Hb FX moves faster than Hb A at alkaline pH
IEF Same results
CHROMATOGRAPHY No separation by cation exchange HPLC
CHAIN SEPARATION GgammaX = 31% of total gamma; AgammaT = 16.4%; Ggamma = 31.5%; Agamma = 21.1%
STRUCTURE STUDIES Tryptic digestion of AE-gammaX chain; separation of peptides by reversed phase HPLC; amino acid analysis
DNA ANALYSES An AAA->CAA mutation at codon 59
NOTES Found in a Spanish newborn, and in a French baby; Hb FX 25% of total Hb
       
REFERENCES
1. Pobedimskaya, D.D., Molchanova, T.P., Gu, L-H., Molina, M.A., de Pablos, J.Ma., and Huisman, T.H.J.: Hemoglobin, 17:269, 1993.
2. Abbes, S., Fitzgerald, P.A., Varady, E., Girot, R., Pic, P., Blouquit, Y., Ducrocq, R., Drupt, F., and Wajcman, H.: Hemoglobin, 19:173, 1995.


This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.