Hb F-Cosenza Ggamma25(B7)Gly->Glu
ELECTROPHORESIS Hb FX moves faster than Hb A at alkaline pH
IEF Hb FX focuses faster than Hb A
CHAIN SEPARATION GgammaX = 23.4%; Ggamma = 41.6%; Agamma = 35%
STRUCTURE STUDIES Tryptic digestion of AE-gammaX chain; separation of peptides by reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation GGA->GAA at codon 25
NOTES Found in an Italian newborn; Hb FX 22.4% of total Hb
1. Qualtieri, A., Crescibene, L., Bagala, A., De Marco, E.V., Bria, M., and Brancati, C.: Hemoglobin, 15:509, 1991.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.