Hb F-Austell | Ggamma40(C6)Arg->Lys |
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ELECTROPHORESIS | Hb FX moves slightly slower than Hb F at alkaline pH | ||
IEF | Not reported | ||
CHROMATOGRAPHY | Hb FX elutes slightly faster than Hb F in cation exchange HPLC | ||
CHAIN SEPARATION | AgammaT = 15%; Ggamma+GgammaX = 73.4%; Agamma = 11.6% | ||
STRUCTURE STUDIES | Tryptic digestion of gammaX chain; separation of peptides by reversed phase HPLC; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation AGG->AAG at codon 40 | ||
NOTES | Found in a Black newborn; baby was also heterozygous for the AgammaT chain; Hb FX 27% of total Hb |
REFERENCES | |||
1. | Kutlar, A., Kutlar, F., Wilson, J.B., Webber, B.B., Hu, H., and Huisman, T.H.J.: Hemoglobin, 12:409, 1988. |