Hb A2-NYU delta12(A9)Asn->Lys
CONTACT External
ELECTROPHORESIS Hb X moves slower than Hb A2; like Hb B2 (see delta16)
IEF Same
CHROMATOGRAPHY Hb X can be isolated by DEAE-cellulose or Sephadex chromatography; Hb X elutes ahead of Hb A2
STRUCTURE ANALYSIS Tryptic digestion of deltaX chain; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSIS Not reported; presumed mutation AAT->AAA at codon 12
NOTES Found in a few Russian, Greek, Ukrainian, Dutch, and Jewish families; also found in combination with beta-thal trait
1. Aksoy, M. and Erdem, S.: Israel J. Med. Sci., 2:310, 1966.
2. Ranney, H.M., Jacobs, A.S., Ramot, B., and Bradley, T.B.: J. Clin. Invest., 48:2057, 1969.
3. Vella, F., Wong, S.C., Wilson, J.B., and Huisman, T.H.J.: Canad. J. Biochem., 50:841, 1972.
4. De Jong, W.W.W. and Went, L.N.: Hum. Hered., 24:32, 1974.
5. Carter, N.D., Casey, R., and Lehmann, H.: Hum. Hered., 25:13, 1974.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.