Hb A2-Indonesia delta69(E13)Gly->Arg
CONTACT External
ELECTROPHORESIS Hb X is slower than Hb A2 and slightly faster than Hb A2' (delta16)
IEF Not reported
CHROMATOGRAPHY Hb X can be isolated by cation and anion exchange HPLC
STRUCTURE ANALYSIS Tryptic digestion of deltaX chain or of Hb X; separation of peptides by fingerprinting or chromatography; amino acid analysis
DNA ANALYSIS Not reported; presumed mutation GGT->CGT at codon 69
NOTES Found at low frequency in the Indonesian and Malay populations; found in association with Hb E and with beta-thal
1. Lie-Injo, L.E., Poey-Oey, H.G., and Mossberger, R.J.: Am. J. Hum. Genet., 20: 470, 1968.
2. Lie-Injo, L.E., Wita, P., Westendorp-Boerma, F., Efremov, G.D., Wilson, J.B., Reynolds, C.A., and Huisman, T.H.J.: Biochim. Biophys. Acta, 229:335, 1971.
3. Ganesan, J. and Lie-Injo, L.E.: Acta Haematol., 59:341, 1978.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.