Hb A2-Fitzroy delta142(H20)Ala->Asp
CONTACT External; central cavity; 2,3-DPG pocket
ELECTROPHORESIS Hb X moves between Hb S and Hb A2 at alkaline pH
IEF About the same
CHROMATOGRAPHY Hb X was isolated by DEAE-Sephadex chromatography
STRUCTURE ANALYSIS Tryptic digestion of Hb X; separation of peptides by fingerprinting; amino acid analysis; sequencing
DNA ANALYSIS Not reported; presumed mutation GCC->GAC at codon 142
NOTES Found in a Greek family
1. Williamson, D., Brennan, S.O., Strosberg, H., Whitty, J., and Carrell, R.W.: Hemoglobin, 8:325, 1984.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.