Hb Yusa beta21(B3)Asp->Tyr
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH; excellent separation by IEF
CHROMATOGRAPHY Hb X and Hb A separate on an anion exchange column
STRUCTURE STUDIES Tryptic digestion; fingerprinting; reversed phase HPLC: amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation GAT->TAT at codon 21
FUNCTION STUDIES Normal oxygen affinity, Bohr, cooperativity, and 2,3-DPG effects
OCCURRENCE Found in two Japanese families
OTHER INFORMATION Quantity in heterozygotes ~41%
1. Harano, T., Harano, K., Ueda, S., Shibata, S., and Iuchi, I.: Hemoglobin, 5:121, 1981.
2. Ohba, Y., Hattori, Y., Ami, M., Yagami, H., Miyaji, T., and Tani, Y.: Hemoglobin, 14:109, 1990.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.