Hb Yahata beta112(G14)Cys->Tyr
CONTACT Internal; central cavity
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A can be separated by IEF; Hb X moves ahead of Hb A
CHROMATOGRAPHY Hb X moves slightly faster than Hb A by cation exchange HPLC
STRUCTURE STUDIES Tryptic digestion of AE-betaX chain; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES A TGT->TAT mutation at codon 112
OCCURRENCE Found in a 27-year-old Japanese male
OTHER INFORMATION Quantity in the heterozygote 45%
1. Harano, T., Harano, K., Kushida, Y., and Ueda, S.: Hemoglobin, 15:109, 1991.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.