Hb Wood beta97(FG4)His->Leu
CONTACT External; alpha1beta2 contact
HEMATOLOGY Erythrocytosis in the heterozygote
ELECTROPHORESIS No separation of Hb X and Hb A by standard techniques; separation is possible by IEF
CHROMATOGRAPHY Hb X can be isolated by cation exchange chromatography
STRUCTURE STUDIES Tryptic digestion of AE-betaX chain; separation of peptides by fingerprinting; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation CAC->CTC at codon 97
FUNCTION STUDIES Increased oxygen affinity; decreased cooperativity; normal Bohr effect
OCCURRENCE Found in a family of Swedish-Norwegian descent
OTHER INFORMATION Quantity in the heterozygote ~50%
1. Taketa, F., Huang, Y.P., Libnoch, J.A., and Dessel, B.H.: Biochim. Biophys. Acta, 400:348, 1975.
2. Taketa, F., Antholine, W.E., Mauk, A.G., and Libnoch, J.A.: Biochemistry, 14: 3229, 1975.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.