Hb Warwickshire beta5(A2)Pro->Arg
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS A slowly-moving variant on paper and cellulose acetate at alkaline pH
STRUCTURE STUDIES Tryptic digestion; fingerprinting; peptide analyses
DNA ANALYSES Not reported; presumed mutation CCT->CGT at codon 5
FUNCTION STUDIES Small decrease in oxygen affinity
STABILITY Slightly unstable
OCCURRENCE Found in a Scottish family
OTHER INFORMATION Quantity in the heterozygote 31-38%
1. Wilson, C.I.D., Cave, R.J., Lehmann, H., Close, M., and Imai, K.: FEBS Lett., 176:331, 1984.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.