Hb Sendagi beta42(CD1)Phe->Val
         
ALSO KNOWN AS Warsaw
CONTACT Heme contact
HEMATOLOGY Moderate hemolytic anemia with reticulocytosis; Heinz bodies
ELECTROPHORESIS No separation reported
CHROMATOGRAPHY No separation by cation or anion exchange chromatography; betaX elutes ahead of betaA in reversed phase HPLC
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting and reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation TTT->GTT at codon 42
FUNCTION STUDIES Decreased oxygen affinity
STABILITY Unstable
OCCURRENCE Found in a Japanese male and his daughter, and in a Polish-American family
OTHER INFORMATION Quantity in heterozygotes estimated at 42-45% (reversed phase HPLC); metHb formation
       
REFERENCES
1. Ogata, K., Ito, T., Kazaki, T., Dan, K., Nomura, T., Nozawa, Y., and Kajita, A.: Hemoglobin, 10:469, 1986.
2. Honig, G.R., Telfer, M.C., Rosenblum, B.B., and Vida, L.N.: Am. J. Hematol., 32:36, 1989.
3. Honig, G.R., Vida, L.N., Rosenblum, B.B., Perutz, M.F., and Fermi, G.: J. Biol. Chem., 265:126, 1990.


This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.